Featured Publications
Verma MS, Tsuji JM, Hall B, Chen PZ, Forrest J, Jones L, Gu FX. Towards point-of-care detection of polymicrobial infections: rapid colorimetric response using a portable spectrophotometer. Sensing and Bio-Sensing Research 2016;10:15-19.

Infectious diseases spread rapidly because current diagnostic methods are slow, expensive, and require technical expertise. Biosensors have recently been used as devices that can be deployed at the point-of-care for rapid and accurate diagnosis. Here, we show that a “chemical nose” biosensor based on gold nanoparticles can be coupled with a portable spectrophotometer to detect monomicrobial and polymicrobial solutions of pathogenic bacteria within 2 min of data collection. The design presented here exploits the rapid kinetics of gold nanoparticle aggregation around bacteria, which leads to a dramatic color change. The “chemical nose” produces unique signals based on the surface characteristics of the bacteria—such as the presence of extracellular polymeric substances, distribution of charged lipids, and localization of proteins—and hence provides a versatile platform for detection. We present a biosensor design that can easily be translated to the point-of-care because of its rapid response and simple output.

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The Sengi team is led by Dr. Brad Hall, a vision scientist and expert medical writer. A regular peer reviewer for several medical and ophthalmology journals, Dr. Hall has authored a multitude of articles personally, is a successful grant writer, medical writer, and master of the art of simplifying data and statistical analysis. Since launching in 2015, Sengi has provided medical writing and biostatistics analysis expertise to SMBs and researchers around the world that lacked the necessary means to share their scientific breakthroughs outside of the lab. Sengi’s work has enabled these companies to put advanced technology into the hands of those who need them most.