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Hall, B, Jones, L, Dixon, B. Silicone allergies and the eye: fact or fiction? Eye & Contact Lens 2014;40(1):51-57.

 

OBJECTIVE

The purpose of this manuscript was to review the evidence concerning the role of an allergic reaction to silicone as the basis for the reported increase in contact lens-associated infiltrates in wearers of silicone hydrogel contact lenses.

METHODS

A literature review was undertaken to investigate the antigenic properties of silicone and the causes of contact lens-associated inflammatory reactions.

RESULTS

Immune cells cannot interact with silicone directly but can interact with antigens on these lenses. These antigens could be due to tear film deposits, microbial contamination, or components of care systems used with these lenses.

CONCLUSIONS

Inflammatory reactions associated with silicone hydrogel contact lens wear are not caused by an allergic reaction to silicone alone.

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The Sengi team is led by Dr. Brad Hall, a vision scientist and expert medical writer. A regular peer reviewer for several medical and ophthalmology journals, Dr. Hall has authored a multitude of articles personally, is a successful grant writer, medical writer, and master of the art of simplifying data and statistical analysis. Since launching in 2015, Sengi has provided medical writing and biostatistics analysis expertise to SMBs and researchers around the world that lacked the necessary means to share their scientific breakthroughs outside of the lab. Sengi’s work has enabled these companies to put advanced technology into the hands of those who need them most.